Portuguese researchers from the Universidade do Porto critically review experimental approaches in tuberculosis research, highlighting the latest advances in 3D in vitro and other human-based models with the potential to advance our understanding of TB infection and treatment. This paper was funded by the BioMed21 Collaboration as part of our “Roadmaps to Human Biology-Based Disease Research” program, which supports independent reviews of the human relevance, translational success and limitations of conventional research models, and recommendations/roadmap for optimizing the funding and use of advanced, human-specific tools and approaches. Our policy is to use OpenAccess publication wherever we can. View the free, full-text version on PlosOne.
Reference: Fonseca KL, Rodrigues PNS, Olsson IAS, Saraiva M. Experimental study of tuberculosis: From animal models to complex cell systems and organoids. PLoS Pathog. 2017 Aug 17;13(8):e1006421.